Featured publications
CSF-Based Volumetric Imaging Biomarkers Highlight Incidence and Risk Factors for Cerebral Edema After Ischemic Stroke
May 15, 2023
Bui Q, Kumar A, Chen Y, Hamzehloo A, Heitsch L, Slowik A, Strbian D, Lee JM, Dhar R. CSF-Based Volumetric Imaging Biomarkers Highlight Incidence and Risk Factors for Cerebral Edema After Ischemic Stroke. Neurocrit Care. 2023 May 15. doi: 10.1007/s12028-023-01742-0. Epub ahead of print. PMID: 37188885.
Imaging biomarkers of cerebral edema automatically extracted from routine CT scans of large vessel occlusion strokes
April 24, 2023
Dhar R, Kumar A, Chen Y, Begunova Y, Olexa M, Prasad A, Carey G, Gonzalez I, Bhatia K, Hamed M, Heitsch L, Mainali S, Petersen N, Lee JM. Imaging biomarkers of cerebral edema automatically extracted from routine CT scans of large vessel occlusion strokes. J Neuroimaging. 2023 Apr 24. doi: 10.1111/jon.13109. Epub ahead of print. PMID: 37095592.
Accelerating Prediction of Malignant Cerebral Edema After Ischemic Stroke with Automated Image Analysis and Explainable Neural Networks
April 1, 2022
Foroushani HM, Hamzehloo A, Kumar A, Chen Y, Heitsch L, Slowik A, Strbian D, Lee JM, Marcus DS, Dhar R. Accelerating Prediction of Malignant Cerebral Edema After Ischemic Stroke with Automated Image Analysis and Explainable Neural Networks. Neurocrit Care. 2022 Apr;36(2):471-482. doi: 10.1007/s12028-021-01325-x. Epub 2021 Aug 20. PMID: 34417703; PMCID: PMC8858326.
Automated Quantification of Reduced Sulcal Volume Identifies Early Brain Injury After Aneurysmal Subarachnoid Hemorrhage
April 1, 2021
Yuan JY, Chen Y, Kumar A, Zlepper Z, Jayaraman K, Aung WY, Clarke JV, Allen M, Athiraman U, Osbun J, Zipfel GJ, Dhar R. Automated Quantification of Reduced Sulcal Volume Identifies Early Brain Injury After Aneurysmal Subarachnoid Hemorrhage. Stroke. 2021 Apr;52(4):1380-1389. doi: 10.1161/STROKEAHA.120.032001. Epub 2021 Feb 16. PMID: 33588595; PMCID: PMC7987771.
Quantitative Serial CT Imaging-Derived Features Improve Prediction of Malignant Cerebral Edema after Ischemic Stroke
December 1, 2020
Foroushani HM, Hamzehloo A, Kumar A, Chen Y, Heitsch L, Slowik A, Strbian D, Lee JM, Marcus DS, Dhar R. Quantitative Serial CT Imaging-Derived Features Improve Prediction of Malignant Cerebral Edema after Ischemic Stroke. Neurocrit Care. 2020 Dec;33(3):785-792. doi: 10.1007/s12028-020-01056-5. Epub 2020 Jul 29. PMID: 32729090; PMCID: PMC7738418.
Reduction in Cerebrospinal Fluid Volume as an Early Quantitative Biomarker of Cerebral Edema After Ischemic Stroke
Februrary 1, 2020
Dhar R, Chen Y, Hamzehloo A, Kumar A, Heitsch L, He J, Chen L, Slowik A, Strbian D, Lee JM. Reduction in Cerebrospinal Fluid Volume as an Early Quantitative Biomarker of Cerebral Edema After Ischemic Stroke. Stroke. 2020 Feb;51(2):462-467. doi: 10.1161/STROKEAHA.119.027895. Epub 2019 Dec 10. PMID: 31818229; PMCID: PMC6991889.
Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage
Februrary 1, 2020
Dhar R, Falcone GJ, Chen Y, Hamzehloo A, Kirsch EP, Noche RB, Roth K, Acosta J, Ruiz A, Phuah CL, Woo D, Gill TM, Sheth KN, Lee JM. Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage. Stroke. 2020 Feb;51(2):648-651. doi: 10.1161/STROKEAHA.119.027657. Epub 2019 Dec 6. PMID: 31805845; PMCID: PMC6993878.
A Randomized Controlled Trial of Naloxone for Optimization of Hypoxemia in Lung Donors After Brain Death
July 1, 2019
Dhar R, Stahlschmidt E, Paramesh A, Marklin G. A Randomized Controlled Trial of Naloxone for Optimization of Hypoxemia in Lung Donors After Brain Death. Transplantation. 2019 Jul;103(7):1433-1438. doi: 10.1097/TP.0000000000002511. PMID: 30399122.
Application of Machine Learning to Automated Analysis of Cerebral Edema in Large Cohorts of Ischemic Stroke Patients
August 21, 2018
Dhar R, Chen Y, An H, Lee JM. Application of Machine Learning to Automated Analysis of Cerebral Edema in Large Cohorts of Ischemic Stroke Patients. Front Neurol. 2018 Aug 21;9:687. doi: 10.3389/fneur.2018.00687. PMID: 30186224; PMCID: PMC6110910.
A Randomized Trial of Brief Versus Extended Seizure Prophylaxis After Aneurysmal Subarachnoid Hemorrhage
April 1, 2018
Human T, Diringer MN, Allen M, Zipfel GJ, Chicoine M, Dacey R, Dhar R. A Randomized Trial of Brief Versus Extended Seizure Prophylaxis After Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2018 Apr;28(2):169-174. doi: 10.1007/s12028-017-0440-5. PMID: 28831717; PMCID: PMC5823718.
Recent publications
- Intraoperative Blood Pressure and Carbon Dioxide Values during Aneurysmal Repair and the Outcomes after Aneurysmal Subarachnoid HemorrhageAthiraman, U., Norris, A. J., Jayaraman, K., Lele, A. V., Kentner, R., Singh, P. M., Higo, O. M., Zipfel, G. J. & Dhar, R., Sep 2023, In: Journal of Clinical Medicine. 12, 17, 5488.Research output: Contribution to journal › Article › peer-review
- Imaging biomarkers of cerebral edema automatically extracted from routine CT scans of large vessel occlusion strokesDhar, R., Kumar, A., Chen, Y., Begunova, Y., Olexa, M., Prasad, A., Carey, G., Gonzalez, I., Bhatia, K., Hamed, M., Heitsch, L., Mainali, S., Petersen, N. & Lee, J. M., Jul 1 2023, In: Journal of Neuroimaging. 33, 4, p. 606-616 11 p.Research output: Contribution to journal › Article › peer-review
- Early Brain Injury After Subarachnoid Hemorrhage: Incidence and MechanismsLauzier, D. C., Jayaraman, K., Yuan, J. Y., Diwan, D., Vellimana, A. K., Osbun, J. W., Chatterjee, A. R., Athiraman, U., Dhar, R. & Zipfel, G. J., May 1 2023, In: Stroke. 54, 5, p. 1426-1440 15 p.Research output: Contribution to journal › Review article › peer-review
- Automated Quantification of Compartmental Blood Volumes Enables Prediction of Delayed Cerebral Ischemia and Outcomes After Aneurysmal Subarachnoid HemorrhageYuan, J. Y., Chen, Y., Jayaraman, K., Kumar, A., Zlepper, Z., Allen, M. L., Athiraman, U., Osbun, J., Zipfel, G. & Dhar, R., Feb 2023, In: World neurosurgery. 170, p. e214-e222Research output: Contribution to journal › Article › peer-review
- Collateral Flow: Prolonging the Ischemic PenumbraDhar, R., Yu, W., Yenari, M. & Lee, J. M., Feb 2023, In: Translational Stroke Research. 14, 1, p. 1-2 2 p.Research output: Contribution to journal › Editorial
- Siam-VAE: A hybrid deep learning based anomaly detection framework for automated quality control of head CT scansGhosh, S. S., Dhar, R., Marcus, D. S. & Sotiras, A., 2023, Medical Imaging 2023: Computer-Aided Diagnosis. Iftekharuddin, K. M. & Chen, W. (eds.). SPIE, 124650X. (Progress in Biomedical Optics and Imaging – Proceedings of SPIE; vol. 12465).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
- CSF-Based Volumetric Imaging Biomarkers Highlight Incidence and Risk Factors for Cerebral Edema After Ischemic StrokeBui, Q., Kumar, A., Chen, Y., Hamzehloo, A., Heitsch, L., Slowik, A., Strbian, D., Lee, J. M. & Dhar, R., 2023, (Accepted/In press) In: Neurocritical Care.Research output: Contribution to journal › Article › peer-review
- Navigating the Ocean of Big Data in Neurocritical CareDhar, R. & Meyfroidt, G., Aug 2022, In: Neurocritical Care. 37, p. 157-159 3 p.Research output: Contribution to journal › Editorial
- A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke SubtypeGeneStroke Consortium and International Stroke Genetics Consortium, Jul 8 2022, In: Frontiers in Cardiovascular Medicine. 9, 940696.Research output: Contribution to journal › Article › peer-review
- Multi-Ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic strokeIbanez, L., Heitsch, L., Carrera, C., Farias, F. H. G., Del Aguila, J. L., Dhar, R., Budde, J., Bergmann, K., Bradley, J., Harari, O., Phuah, C. L., Lemmens, R., Souza, A. A. V. O., Moniche, F., Cabezas-Juan, A., Arenillas, J. F., Krupinksi, J., Cullell, N., Torres-Aguila, N., Muiño, E., & 56 othersCárcel-Márquez, J., Marti-Fabregas, J., Delgado-Mederos, R., Marin-Bueno, R., Hornick, A., Vives-Bauza, C., Navarro, R. D., Tur, S., Jimenez, C., Obach, V., Segura, T., Serrano-Heras, G., Chung, J. W., Roquer, J., Soriano-Tarraga, C., Giralt-Steinhauer, E., Mola-Caminal, M., Pera, J., Lapicka-Bodzioch, K., […]