Featured publications
Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors
November 30, 2023
Dhar R, Marklin GF, Klinkenberg WD, Wang J, Goss CW, Lele AV, Kensinger CD, Lange PA, Lebovitz DJ. Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors. N Engl J Med. 2023 Nov 30;389(22):2029-2038. doi: 10.1056/NEJMoa2305969. PMID: 38048188; PMCID: PMC10752368.
CSF-Based Volumetric Imaging Biomarkers Highlight Incidence and Risk Factors for Cerebral Edema After Ischemic Stroke
May 15, 2023
Bui Q, Kumar A, Chen Y, Hamzehloo A, Heitsch L, Slowik A, Strbian D, Lee JM, Dhar R. CSF-Based Volumetric Imaging Biomarkers Highlight Incidence and Risk Factors for Cerebral Edema After Ischemic Stroke. Neurocrit Care. 2023 May 15. doi: 10.1007/s12028-023-01742-0. Epub ahead of print. PMID: 37188885.
Imaging biomarkers of cerebral edema automatically extracted from routine CT scans of large vessel occlusion strokes
April 24, 2023
Dhar R, Kumar A, Chen Y, Begunova Y, Olexa M, Prasad A, Carey G, Gonzalez I, Bhatia K, Hamed M, Heitsch L, Mainali S, Petersen N, Lee JM. Imaging biomarkers of cerebral edema automatically extracted from routine CT scans of large vessel occlusion strokes. J Neuroimaging. 2023 Apr 24. doi: 10.1111/jon.13109. Epub ahead of print. PMID: 37095592.
Accelerating Prediction of Malignant Cerebral Edema After Ischemic Stroke with Automated Image Analysis and Explainable Neural Networks
April 1, 2022
Foroushani HM, Hamzehloo A, Kumar A, Chen Y, Heitsch L, Slowik A, Strbian D, Lee JM, Marcus DS, Dhar R. Accelerating Prediction of Malignant Cerebral Edema After Ischemic Stroke with Automated Image Analysis and Explainable Neural Networks. Neurocrit Care. 2022 Apr;36(2):471-482. doi: 10.1007/s12028-021-01325-x. Epub 2021 Aug 20. PMID: 34417703; PMCID: PMC8858326.
Automated Quantification of Reduced Sulcal Volume Identifies Early Brain Injury After Aneurysmal Subarachnoid Hemorrhage
April 1, 2021
Yuan JY, Chen Y, Kumar A, Zlepper Z, Jayaraman K, Aung WY, Clarke JV, Allen M, Athiraman U, Osbun J, Zipfel GJ, Dhar R. Automated Quantification of Reduced Sulcal Volume Identifies Early Brain Injury After Aneurysmal Subarachnoid Hemorrhage. Stroke. 2021 Apr;52(4):1380-1389. doi: 10.1161/STROKEAHA.120.032001. Epub 2021 Feb 16. PMID: 33588595; PMCID: PMC7987771.
Quantitative Serial CT Imaging-Derived Features Improve Prediction of Malignant Cerebral Edema after Ischemic Stroke
December 1, 2020
Foroushani HM, Hamzehloo A, Kumar A, Chen Y, Heitsch L, Slowik A, Strbian D, Lee JM, Marcus DS, Dhar R. Quantitative Serial CT Imaging-Derived Features Improve Prediction of Malignant Cerebral Edema after Ischemic Stroke. Neurocrit Care. 2020 Dec;33(3):785-792. doi: 10.1007/s12028-020-01056-5. Epub 2020 Jul 29. PMID: 32729090; PMCID: PMC7738418.
Reduction in Cerebrospinal Fluid Volume as an Early Quantitative Biomarker of Cerebral Edema After Ischemic Stroke
Februrary 1, 2020
Dhar R, Chen Y, Hamzehloo A, Kumar A, Heitsch L, He J, Chen L, Slowik A, Strbian D, Lee JM. Reduction in Cerebrospinal Fluid Volume as an Early Quantitative Biomarker of Cerebral Edema After Ischemic Stroke. Stroke. 2020 Feb;51(2):462-467. doi: 10.1161/STROKEAHA.119.027895. Epub 2019 Dec 10. PMID: 31818229; PMCID: PMC6991889.
Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage
Februrary 1, 2020
Dhar R, Falcone GJ, Chen Y, Hamzehloo A, Kirsch EP, Noche RB, Roth K, Acosta J, Ruiz A, Phuah CL, Woo D, Gill TM, Sheth KN, Lee JM. Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage. Stroke. 2020 Feb;51(2):648-651. doi: 10.1161/STROKEAHA.119.027657. Epub 2019 Dec 6. PMID: 31805845; PMCID: PMC6993878.
Application of Machine Learning to Automated Analysis of Cerebral Edema in Large Cohorts of Ischemic Stroke Patients
August 21, 2018
Dhar R, Chen Y, An H, Lee JM. Application of Machine Learning to Automated Analysis of Cerebral Edema in Large Cohorts of Ischemic Stroke Patients. Front Neurol. 2018 Aug 21;9:687. doi: 10.3389/fneur.2018.00687. PMID: 30186224; PMCID: PMC6110910.
A Randomized Trial of Brief Versus Extended Seizure Prophylaxis After Aneurysmal Subarachnoid Hemorrhage
April 1, 2018
Human T, Diringer MN, Allen M, Zipfel GJ, Chicoine M, Dacey R, Dhar R. A Randomized Trial of Brief Versus Extended Seizure Prophylaxis After Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2018 Apr;28(2):169-174. doi: 10.1007/s12028-017-0440-5. PMID: 28831717; PMCID: PMC5823718.
Recent publications
- Caring for Coma after Severe Brain Injury: Clinical Practices and Challenges to Improve Outcomes: An Initiative by the Curing Coma CampaignCuring Coma Collaborators, Apr 2025, In: Neurocritical Care. 42, 2, p. 325-333 9 p., 101432.Research output: Contribution to journal › Article › peer-review
- Early automated cerebral edema assessment following endovascular therapy: impact on stroke outcomeGuasch-Jiménez, M., Dhar, R., Kumar, A., Cifarelli, J., Ezcurra-Díaz, G., Lambea-Gil, Á., Ramos-Pachón, A., Martínez-Domeño, A., Prats-Sánchez, L., Guisado-Alonso, D., Fernández-Cadenas, I., Aguilera-Simón, A., Marín, R., Martínez-González, J. P., Ortega-Quintanilla, J., Fernández-Pérez, I., Avellaneda-Gómez, C., Rodríguez-Pardo, J., De Celis, E. & Moniche, F. & 5 others, Freijo, M. D. M., Cortijo, E., Trillo, S., Camps-Renom, P. & Martí-Fábregas, J., Jan 25 2025, In: Journal of NeuroInterventional Surgery. 15, 021641.Research output: Contribution to journal › Article › peer-review
- Intravenous glibenclamide for cerebral oedema after large hemispheric stroke (CHARM): a phase 3, double-blind, placebo-controlled, randomised trialCHARM Trial investigators, Dec 2024, In: The Lancet Neurology. 23, 12, p. 1205-1213 9 p.Research output: Contribution to journal › Article › peer-review
- A Recruitment Maneuver After Apnea Testing Improves Oxygenation and Reduces Atelectasis in Organ Donors After Brain DeathDhar, R., Braun, P., Kumar, A., Patel, J., Lee, F. L. & Arshi, B., Oct 2024, In: Neurocritical Care. 41, 2, p. 576-582 7 p.Research output: Contribution to journal › Article › peer-review
- Evaluating the interaction between hemorrhagic transformation and cerebral edema on functional outcome after ischemic strokeAvula, A., Bui, Q., Kumar, A., Chen, Y., Hamzehloo, A., Cifarelli, J., Heitsch, L., Slowik, A., Strbian, D., Lee, J. M. & Dhar, R., Oct 2024, In: Journal of Stroke and Cerebrovascular Diseases. 33, 10, 107913.Research output: Contribution to journal › Article › peer-review
- Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar StrokeCárcel-Márquez, J., Muiño, E., Gallego-Fabrega, C., Cullell, N., Lledós, M., Llucià-Carol, L., Martín-Campos, J. M., Sobrino, T., Campos, F., Castillo, J., Freijo, M., Arenillas, J. F., Obach, V., Álvarez-Sabín, J., Molina, C. A., Ribó, M., Jiménez-Conde, J., Roquer, J., Muñoz-Narbona, L. & Lopez-Cancio, E. & 22 others, Millán, M., Diaz-Navarro, R., Vives-Bauza, C., Serrano-Heras, G., Segura, T., Ibañez, L., Heitsch, L., Delgado, P., Dhar, R., Krupinski, J., Prats-Sánchez, L., Camps-Renom, P., Guasch, M., Ezcurra, G., Blay, N., Sumoy, L., De Cid, R., Montaner, J., Cruchaga, C., […]
- Conditioning-based therapeutics for aneurysmal subarachnoid hemorrhage – A critical reviewPugazenthi, S., Norris, A. J., Lauzier, D. C., Lele, A. V., Huguenard, A., Dhar, R., Zipfel, G. J. & Athiraman, U., Mar 2024, In: Journal of Cerebral Blood Flow and Metabolism. 44, 3, p. 317-332 16 p.Research output: Contribution to journal › Review article › peer-review
- Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors. ReplyDhar, R. & Marklin, G. F., Feb 8 2024, In: The New England journal of medicine. 390, 6, p. 575-576 2 p.Research output: Contribution to journal › Letter › peer-review
- Collateral Status, Reperfusion, and Cerebral Edema After Thrombectomy for StrokeDhar, R., Feb 2024, In: Neurocritical Care. 40, 1, p. 42-44 3 p.Research output: Contribution to journal › Comment/debate
- CSF-Based Volumetric Imaging Biomarkers Highlight Incidence and Risk Factors for Cerebral Edema After Ischemic StrokeBui, Q., Kumar, A., Chen, Y., Hamzehloo, A., Heitsch, L., Slowik, A., Strbian, D., Lee, J. M. & Dhar, R., Feb 2024, In: Neurocritical Care. 40, 1, p. 303-313 11 p.Research output: Contribution to journal › Article › peer-review